ANIEMEKA, CHIOMA BLESSING. (2025) SYNTHESIS, CHARACTERIZATION OF SUBSTITUTED SULPHONAMIDOBENZAMIDE DERIVATIVES AND THEIR IN SILICO AND IN VITRO STUDIES. Other thesis, GODFREY OKOYE UNIVERSITY, ENUGU.
Full text not available from this repository.Abstract
The synthesis of sulphonamidobenzamide derivaties and their in silico and in vitro studies were carried out as reported. The key intermediate 3,5-bis((4-nitrophenyl)sulphonamido) benzoic acid was synthesized via a base catalyzed reaction of 4-nitrobenzenesulphonyl chloride with 3,5-diaminobenzoic acid in 80.5% yield. The treatment of the key intermediate above with six different aromatic amines namely; (4-chloroaniline, 4-bromoaniline, 1- naphthyamine, morpholine, piperlidine, pyrrolidine) in the presence of phenylboronic acid, gave six different sulphonamidobenzamide derivatives in 80-86% yields. The spectra data obtained from Fourier Transform Infrared (FTIR), were: 3534 - 3444 (OH stretch), 3347 - 3279.7 (NH stretch), 3090 -.2934 (C-H stretch), 1735 - 1676 (C=O stretch), 1612 - 1525 (C=C stretch) and 1333 - 1307 (S=O vibration). Proton signals in NMR (ẟ H ) were observed at 10.77 - 10.20 (NH), 8.35 - 6.00 (Ar-H), 3.82 – 1.60 (Al-H). 13 C signals in NMR (ẟ C ) were found at 177.2 - 153.6 (carbonyl carbons), 150.1 - 118.6 (aromatic carbons) 63.9 - 45.5 (aliphatic carbons). The in silico studies were done using AutoDock Vina software (version 4.2). The binding energies (kcal/mol) for in silico antibacterial and antifungal studies were in the range 8.6, 10.4, 9.7, 9.4, 9.4, 9.4, 8.0 and 7.0, for E. coli, S. aureus and candida alibi respectively. When the protein target 6.3, 7.0 and 4.5 were used. The in vitro antimicrobial studies of the synthesized compounds were done via Agar well diffusion method against E.coli, S. aureus and candida alibi with ciprofloxacin and Fluconazolas standard drugs. The minimum inhibitory concentration (MIC) value for the antimicrobial studies were in the range 3mm – 19mm. the synthesized compounds exhibited promising biological activates and can serve as raw materials for drugs synthesis.
| Item Type: | Thesis (Other) |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Natural Sciences and Environmental Studies |
| Depositing User: | HILARY OBIEKWE |
| Date Deposited: | 26 Aug 2026 10:24 |
| Last Modified: | 26 Aug 2026 10:24 |
| URI: | http://eprints.gouni.edu.ng/id/eprint/6305 |
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