Prospects of Phytochemicals for the Treatment of Helminthiasis

Akram, Muhammad and Mohiuddin, Ejaz and Adetunji, Charles Oluwaseun and Oladosun, Tolulope Olawumi and Ozolua, Phebean and Olisaka, Frances N. and Olugbenga, Samuel Micheal and Adetunji, Juliana Bunmi and Hameed, Leena and Awuchi, Chinaza Godswill and Patrick- Iwuanyanwu, Kingsley C. and Olaniyan, Olugbemi Tope (2022) Prospects of Phytochemicals for the Treatment of Helminthiasis. In: Neglected Tropical Diseases and Phytochemicals in Drug Discovery. John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA, pp. 201-224. ISBN 9781119616603

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Abstract

Helminthiasis is a common intestinal worm infection found amongst urban and rural populations [1]. From the beginning of human existence, medicinal plants have been used to treat diseases [2–4]. Recently, there has been a growing revival to treat helminthiasis with medicinal plants [5–8]. Various medicinal plants have an ancient history in terms of helminthiasis treatment in traditional systems of medicine. Intestinal worm infections are increasing worldwide. The most serious helminthiasis infections are prevalent in the developing countries, but can also be found across the developed countries. The most common soil- transmitted hel minths are parasitic worms from the phyla Nematoda (roundworms) and Platyhelminthes (flatworms); which includes Hookworms (Ancylostoma duode nale and Necator americanus), roundworm (Ascaris lumbricoides), and whipworm (Trichuris trichiura). Approximately 4.5 billion people are at risk of being infected by helminths [9, 10]. All ages are affected by intestinal parasitic infections (IPIs) but children, preschool, and school- going children are the high- risk group and this disease is responsible for poor health and malnutrition. Recurrent infections lead to excess morbidity that can continue from generation to generation in the already poor group of people who are at risk of this disease because of lack of sani tation, lack of access to safe water, and improper hygiene. So, it is most common wherever there are poverty and economic instability [11]. A. lumbricoides is the most common helminth and currently infects about 1 billion people world wide [12]. Figure 7.1 depicts an Ascaris worm being removed from a patient’s bile duct in South Africa.

Item Type:	Book Section
Subjects:	Q Science > QR Microbiology
Divisions:	Faculty of Natural and Applied Sciences
Depositing User:	mrs chioma hannah
Date Deposited:	31 Aug 2025 13:32
Last Modified:	31 Aug 2025 13:32
URI:	http://eprints.gouni.edu.ng/id/eprint/5407

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