Anyaoku, C.I and Igwilo, I.O and Ezekwesili, Chinwe Nonyelum and Okafor, Okechukwu Christopher and Agbara, Amaka Cecilia (2024) RENAL AND HEPATIC IMPACTS OF CURCUMA LONGA AND MENTHA PIPERITA IN ALBINO RATS. International Research Journal of Modernization in Engineering Technology and Science, 6 (8). pp. 2982-2990.
![[img]](https://eprints.gouni.edu.ng/style/images/fileicons/text.png) |
Text
RENAL-AND-HEPATIC-IMPACTS-OF-CURCUMA-LONGA-AND-MENTHA-PIPERITA-IN-ALBINO-RATS - Copy.pdf Download (751kB) |
Abstract
The liver and kidney are organs that are easily affected by toxic substances, as result of their various roles in processing, biotransformation and excretion of substances. Herbs and many plant materials are among the numerous substances that can have direct impact on the liver and kidney. Curcuma longa and Mentha piperita are spices commonly used for culinary, pharmacological and medicinal purposes in Nigeria. This study was done to determine, the effects of the individual plants as well as their combination on the kidney and liver functions of albino rats. Forty-two albino rats of mixed gender, excluding pregnant animals were used for the experiment which lasted for 6 weeks, during which, animals were fed with commercial rat pellets and plant samples (in different percentages). The animals were divided into seven groups. Group A (Normal Control group), were fed with commercial rat pellets. The experimental groups comprised of Group B (2.5% turmeric), Group C (10% turmeric), Group D (2.5% mint leaves), Group E (10% mint leaves), Group F (2.5%, 1:1 of both plants) and Group G (10% 1:1 of both plants). After 6 weeks of feeding, animals were sacrificed, serum was collected and assayed for kidney and liver functions. Standard methods and procedures were used to check for urea, creatinine and total protein for the kidneys. ALT, AST and Albumin levels were used to check for liver function and histopathological examinations were done for both organs. The results showed a significant nonconcentration dependent increase in urea level in the experimental groups (p<0.05). There was also nonsignificant increase in creatinine level in most of the experimental groups, especially the Curcuma longa (groups B and C). The liver function tests showed, a significant reduction in ALT activity (p<0.05) in most of the experimental groups except the 10% mentha piperita leaves group (group E). There was a significant dose dependent increase in AST activity (p<0.05) in the experimental groups compared to the control. There was a non-significant (p˃0.05) lower albumin concentration in the experimental groups compared to the control. Histopathological evaluation showed normal kidney tissues in all groups, but revealed abnormal liver tissues in groups C, E and G animals. Therefore, it can be inferred that both plants may have the potential to cause deleterious effects on the kidneys and especially the liver, when taken at high concentrations over prolonged period of time.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Natural and Applied Sciences |
| Depositing User: | Uchenna Eneogwe |
| Date Deposited: | 29 Aug 2025 14:34 |
| Last Modified: | 29 Aug 2025 14:34 |
| URI: | http://eprints.gouni.edu.ng/id/eprint/5383 |
Actions (login required)
 |
View Item |
