Baseline Renal Function among Antiretroviral Therapy-Naive, HIV-Infected Patients in Southeast Nigeria

Onodugo, Obinna D. and Chukwuka, Chinwe and Onyedum, Cajetan and Ejim, Emmanuel and Nkwo, Peter and Ukoma, Ubani and Anyene, Chukwujekwu and Obi, Frank and Uche, Ikenna and Mbah, Anthony and Ugwu, George and Nwabueze, Emmanuel and Akabueze, Jude and Ekochin, Fintan Chinweike and Nnoruka, Edith (2014) Baseline Renal Function among Antiretroviral Therapy-Naive, HIV-Infected Patients in Southeast Nigeria. Journal of the International Association of Providers of AIDS Care, 13 (5). pp. 476-480.

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Abstract

Background: Renal insufficiency has been shown to be a significant, independent risk factor for mortality among HIV-infected patients. Unfortunately, little is known about the prevalence and nature of renal impairment in African populations initiating anti retroviral treatment. This study aims to find the prevalence of abnormal renal function among antiretroviral therapy (ART)-naive, HIV-infected patients in the South Eastern geopolitical zone of Nigeria. Method: This is a cross-sectional hospital-based study, involving 300 ART-naive HIV-positive patients, seen over a 1-year period, aged from 18 years and older, presenting to the clinic for the first time. Results: A total of 300 patients were included in the study, 104 (34.7%) males and 196 (65.3%) females. The prevalence of significant renal disease was 24.3% (73 of 300), while 38.3% (115 of 300) had mild renal impairment. Using logistic regression, age, CD4 count, urea, creatinine, and hemoglobin were significantly associated with renal impairment. Conclusion: The authors observed a high prevalence of significant renal impairment among HIV-infected patients at the time of ART initiation.

Item Type: Article
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: mrs chioma hannah
Date Deposited: 02 Jul 2025 11:35
Last Modified: 02 Jul 2025 11:35
URI: http://eprints.gouni.edu.ng/id/eprint/4950

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