Anorue, Chukwuemeka Eleazar and Joshua, Parker Elijah (2025) Anacardium occidentale L. nuts: an anti-sickling agent for sickle cell beta-thalassemia. Comparative Clinical Pathology. pp. 1-14.
Full text not available from this repository.Abstract
Sickle cell disease (SCD) is among the most common hemoglobin (Hb) disorders globally. Current allopathic treatment options are only palliative and costly and have huge adverse reactions. Presently, plants with therapeutic properties are being explored for the management of SCD because while ofering a better treatment option, they have little or no side efects. Anacardium occidentale L. has been utilized in traditional medicine for managing many life-threatening diseases and is suggested to be efective in managing SCD. This study seeks to explore the potential of A. occidentale nut for the treatment of a form of SCD called sickle cell beta-thalassemia (SCD-S/β). The study comprises four groups: group 1 (the group without treatment), group 2 (group administered the standard medication), group 3 (group administered 500 µg/mL of A. occidentale nut extract), and group 4 (group administered 1000 µg/mL of A. occidentale nut extract). Analysis, such as reversibility test, polymerization studies, osmotic fragility assay, and deoxygenation studies, was used to measure the anti-sickling properties of A. occidentale nut extract on SCD-S/β. A. occidentale nut extract led to dose-dependent reversal of the sickled red blood cells, decreased both the rate of polymerization and haemolysis, prevented deoxygenation of beta-thalassemia hemoglobin (Hb-S/β), and increased the oxy-hemoglobin (Oxy-Hb) concentration. The present study suggests that A. occidentale nut exhibit a therapeutic efect on SCD-S/β and can serve as an efective treatment for the management of SCD-S/β.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Natural and Applied Sciences |
| Depositing User: | Uchenna Eneogwe |
| Date Deposited: | 20 Jun 2025 09:31 |
| Last Modified: | 20 Jun 2025 09:31 |
| URI: | http://eprints.gouni.edu.ng/id/eprint/4877 |
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