Anti-inflammatory and anti-oxidant activities of Schumanniophyton magnificum leaves: In vivo and in vitro approaches

Anosike, C. Joy and Ikechukwu, Kingsley Ijeoma and Jachike, Aneke Rowland and Parker, Elijah Joshua (2024) Anti-inflammatory and anti-oxidant activities of Schumanniophyton magnificum leaves: In vivo and in vitro approaches. Tropical Journal of Drug Research, 1 (1). pp. 9-18.

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Abstract

Purpose: To investigate the methanol extract of Schumanniophyton magnificum leaves' (MESM-L) anti inflammatory and antioxidant properties Methods: Acute toxicity studies were carried out for 24 hours. Albino rats were randomized into five groups for in vivo anti-inflammatory studies using three models namely egg albumin-induced paw edema, acetic acid-induced vascular permeability, and in vivo leukocyte mobilization assay. Groups include the control, standard and experimental groups (100, 200 and 400 mg/kg b.w. of MESM-L). Membrane stabilization and anti-platelet aggregatory response were carried out at the concentrations 0.1 – 0.8 mg/ml. Nitric oxide, 1, 1-diphenyl-2- picrylhydrazyl, and ferric-reducing antioxidant power assays were employed for anti-oxidant studies. Results: : In acute toxicity investigations, MESM-L was found to be non-toxic at the maximum dose of 5000 mg/kg b.w. MESM-L (400 mg/kg b.w) inhibited edema by 73.13% and inhibited vascular permeability by 72.37%. A profound effect of MESM-L on leukocyte mobilization was detected at the lowest dose (41.17%). Inhibition of hemolysis and aggregation of platelets was exhibited with highest concentration of MESM-L on membrane stabilization and anti-platelet aggregatory. MESM-L scavenged NO and DPPH radical- with IC50 values of 19.52 and 12.31 μg/mL in that order. The effect of gallic acid on FRAP assay was found to be higher than MESM-L. Conclusion: These findings proved the anti-inflammatory potential of MESM-L, although the activities exhibited by the standard drugs were significantly higher. The capacity of the plant to scavenge free radicals is responsible for the effects that have been discovered.

Item Type:	Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Natural and Applied Sciences
Depositing User:	Uchenna Eneogwe
Date Deposited:	03 Jun 2025 09:19
Last Modified:	03 Jun 2025 09:19
URI:	http://eprints.gouni.edu.ng/id/eprint/4735

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