Udoakang, John Aniefiok and Zune, Alexandra Lindsey Djomkam and Tapela, Kesego and Nganyewo, Nora Nghochuzie and Olisaka, Frances N. and Anyigba, Claudia Adzo and Tawiah-Eshun, Sylvia and Owusu, Irene Amoakoh and Paemka, Lily and Awandare, Gordon A. and Quashie, Peter Kojo (2023) The COVID-19, tuberculosis and HIV/AIDS: Ménage à Trois. Frontiers in Immunology, 14 (1). pp. 1-8.
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Abstract
In December 2019, a novel pneumonic condition, Coronavirus disease 2019 (COVID- 19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in China and spread globally. The presentation of COVID-19 is more severe in persons with underlying medical conditions such as Tuberculosis (TB), Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) and other pneumonic conditions. All three diseases are of global concern and can significantly affect the lungs with characteristic cytokine storm, immune suppression, and respiratory failure. Co-infections of SARS-CoV-2 with HIV and Mycobacterium tuberculosis (Mtb) have been reported, which may influence their pathogenesis and disease progression. Pulmonary TB and HIV/AIDS patients could be more susceptible to SARS-CoV-2 infection leading to lethal synergy and disease severity. Therefore, the biological and epidemiological interactions of COVID-19, HIV/AIDS, and TB need to be understood holistically. While data is needed to predict the impact of the COVID-19 pandemic on these existing diseases, it is necessary to review the implications of the evolving COVID-19 management on HIV/AIDS and TB control, including therapy and funding. Also, the impact of long COVID on patients, who may have this co-infection. Thus, this review highlights the implications of COVID-19, HIV/AIDS, and TB co-infection compares disease mechanisms, addresses growing concerns, and suggests a direction for improved diagnosis and general management.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | Uchenna Eneogwe |
| Date Deposited: | 29 May 2025 14:25 |
| Last Modified: | 29 May 2025 14:25 |
| URI: | http://eprints.gouni.edu.ng/id/eprint/4689 |
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