IN VITRO EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY OF THE POLYPHENOL-RICH FRACTION OF Craterosiphon scandens LEAVES

JIDEONWO, CHUKWUEMEZIE OGUGUA (2025) IN VITRO EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY OF THE POLYPHENOL-RICH FRACTION OF Craterosiphon scandens LEAVES. Other thesis, GODFREY OKOYE UNIVERSITY, ENUGU.

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Abstract

Inflammatory reactions play key roles in various pathologic processes. The search and discovery of natural, less harmful anti-inflammatory drugs remains one of the scientific priorities. The in-vitro anti-inflammatory potential of polyphenol-rich fraction of Craterosiphon scandens leaves was evaluated via its effects on phospholipase A 2 activity, proteinase activity, calcium chloride-induced platelet aggregation and albumin denaturation. It was observed that the extract inhibited phospholipase A 2 activity to significant extent at a concentration of 50 mg/ml, which produced the highest inhibition of 60.24% as compared to all the tested concentrations of the reference anti-inflammatory drug, ibuprofen. There was moderate inhibition of proteinase activity by the extract (37.52% at 100 mg/ml) as compared to ibuprofen (50.30%). Inhibition of platelet aggregation was also remarkable with the extract showing 71.43% inhibition which was similar to that of ibuprofen (72.34%) at the same concentration. However, the polyphenol-rich fraction performed less effectively in inhibiting albumin denaturation, with a maximum inhibition of 19.65% at 10 mg/ml, compared to ibuprofen's 24.88%. These findings suggest that the polyphenol-rich fraction of Craterosiphon scandens can be explored as potential therapeutic agent for the treatment of inflammatory disorders.

Item Type:	Thesis (Other)
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Natural and Applied Sciences
Depositing User:	Uchenna Eneogwe
Date Deposited:	02 Jun 2026 09:02
Last Modified:	04 Jun 2026 07:58
URI:	http://eprints.gouni.edu.ng/id/eprint/5715

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