Anti‑hyperglycaemic effect of n‑hexane fraction of Lepidagathis alopecuroides leaves in alloxan‑induced diabetic rats

Ukam, Egwu Endurance and Njoku, D.I. and Ogugofor, Martins and Anorue, Chukwuemeka Eleazar (2024) Anti‑hyperglycaemic effect of n‑hexane fraction of Lepidagathis alopecuroides leaves in alloxan‑induced diabetic rats. Comparative Clinical Pathology. pp. 1-13.

[img] Text
Anti‑hyperglycaemic effect of n‑hexane fraction of Lepidagathis alopecuroides.pdf
Download (2MB)

Abstract

Diabetes remains a prominent cause of mortality in numerous developing nations. Hitherto, there is no cure for diabetes. Since time immemorial, medicinal plants have been explored for the treatment and management of diabetes. This study aimed to explore the anti-hyperglycaemic effects of the n-hexane fraction extracted from L. alopecuroides leaves in alloxan-induced diabetic rats. Twenty-four adult Wister rats were utilized, distributed across six groups, each consisting of four rats. Group 1 served as the normal control (i.e. were neither inducted nor treated), group 2 as the positive control (were inducted but were not treated) and group 3 as the standard control (were inducted and treated with the standard drug; glibenclamide). Groups 4, 5 and 6 received doses of 100, 200 and 400 mg/kg b.w of the L. alopecuroides leaf fraction. The treatment spanned 14 days, during which blood glucose levels, insulin levels, haematological parameters, histological features and other biochemical indicators were assessed. The findings indicated a significant reduction in blood glucose levels, significant increase in insulin levels, proper modulation of the haematological parameters and the restoration of normal pancreatic histoarchitecture in diabetic rats treated with L. alopecuroides leaf extract. This suggests that n-hexane fraction of L. alopecuroides possesses potential as an anti-diabetic agent.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Natural and Applied Sciences
Depositing User: Uchenna Eneogwe
Date Deposited: 20 Jun 2025 14:42
Last Modified: 20 Jun 2025 14:42
URI: http://eprints.gouni.edu.ng/id/eprint/4883

Actions (login required)

View Item View Item
GOUNI Repository is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.