Anorue, Chukwuemeka Eleazar and Joshua, Parker Elijah and Asogwa, Onyinyechi Chinwedu (2025) Evaluation of anti‑infammatory and anti‑oxidant properties of Anacardium occidentale leaf. Infammopharmacology. pp. 1-25.
Full text not available from this repository.Abstract
Infammation is a critical factor in various chronic diseases, and the search for natural anti-infammatory agents has gained attention. This study investigates the anti-infammatory potential of Anacardium occidentale (cashew) leaf extract. A preliminary phytochemical screening revealed the presence of bioactive compounds, with alkaloids (1.667±0.004 mg/ml) and saponins (1.568±0.001 mg/ml) as the most abundant. These compounds, along with favonoids, phenolics, terpenoids, and steroids, are known for their pharmacological properties, including infammation modulation. The study utilized various antioxidant assays, including DPPH, FRAP, and total antioxidant capacity (TAC), which demonstrated signifcant radical scavenging activity, indicating the extract's potential to reduce oxidative stress-induced infammation. The ethanol extract exhibited notable inhibition of protein denaturation, protease activity, lipid peroxidation, nitric oxide scavenging, and phospholipase A2 (PLA2) activity, supporting its anti-infammatory potential. Molecular docking analysis revealed strong binding interactions between the plant's phytochemicals and key infammatory proteins, with favone, myricetin, and catechin displaying superior binding afnity compared to standard anti-infammatory drugs like diclofenac and ibuprofen. These fndings suggest that A. occidentale leaf extract possesses signifcant anti-infammatory and antioxidant properties, likely due to its rich phytochemical composition. The extract's ability to inhibit key infammatory pathways highlights its potential as a natural therapeutic agent for managing infammation-related diseases such as arthritis, asthma, neuro-infammation, and metabolic disorders. Further clinical studies are recommended to validate its efcacy and explore its potential integration into conventional medicine.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Natural and Applied Sciences |
| Depositing User: | Uchenna Eneogwe |
| Date Deposited: | 20 Jun 2025 11:37 |
| Last Modified: | 20 Jun 2025 11:37 |
| URI: | http://eprints.gouni.edu.ng/id/eprint/4880 |
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