Assessment of the anti-ulcer action of the leaves of calopo (Calopogonium mucunoides Desv) in Wistar rats

Enechi, Osmund Chukwuma and Odo, Christian E. and Okafor, Chisom (2014) Assessment of the anti-ulcer action of the leaves of calopo (Calopogonium mucunoides Desv) in Wistar rats. Journal of Pharmacy Research, 8 (1). pp. 24-27. ISSN 0974-6943

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Abstract

Background and Aim: The leaves of Calopogonium mucunoides is used in South Eastern Nigeria for the management of ulcer. Thus, the phytochemical constituents, acute toxicity and anti-ulcer effect of the ethanol extract of the leaves of C. mucunoides using ethanol-induced model of gastric ulceration in rats were evaluated. Methods : The anti-ulcer action of the extract was assessed by determining the volume of gastric juice secretion, ulcer index (length of gastric lesions) and concentrations of the free and total acidity with the aid of standard methods. Results : The phytochemical analyses of the extract revealed the presence of alkaloids, flavonoids, tannins and terpenoids. The extract at a dose as high as 5000 mg/kg body weight (b.w) was not toxic. The extract at the tested doses (100 and 300 mg/kg b.w) caused significant (p < 0.05) dose dependent reductions in the volume of gastric juice secretion, ulcer index and concentrations of the free and total acidity in the treated rats. The anti-ulcer effect exhibited by the extract was comparable with that obtained for the standard anti-ulcer drug [ranitidine (150 mg/kg b.w)]. Conclusion : These findings indicate that the ethanol extract of the leaves of C. mucunoides has remarkable anti-ulcer effect and therefore, lends believability to its use in folk medicine for the management of ulcer.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural and Applied Sciences
Depositing User: Uchenna Eneogwe
Date Deposited: 02 Jun 2025 12:49
Last Modified: 02 Jun 2025 12:49
URI: http://eprints.gouni.edu.ng/id/eprint/4722

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