Enechi, Osmund Chukwuma and Sunday, Okeke Emmanuel and Ethel, Nkwoemeka Ndidi and Timothy, Ezeorba Chidike Prince (2022) Therapeutic Evaluation of the Antioxidant Capacity of Flavonoid-Rich Seed Extract of Buchholzia coriacea Engler (Capparaceae) †. Proceedings. pp. 1-8.
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Abstract
Inflammation is a complex process frequently associated with pain and fever, involving increased vascular permeability, increased protein denaturation, and alteration of the membrane. The clinical symptoms such as fever, aches, and pains associated with several diseases are directly or indirectly due to inflammatory disorders. Most biological proteins lose their biological activities or functions when denatured. An evergreen shrub which is distributed in African countries including Nigeria, among others, belonging to the family of Capparidaceae has been used in traditional medicine as a valuable alternative therapy in the treatment of Malaria, asthma and cough, diarrhoea, rheumatism, ulcers, worm infection, diabetes, hypertension, psychiatric disorders, and impotence. This work studies the anti-inflammatory and antioxidant performance of a flavonoid-rich extract of Buchholzia coriacea Engler (Capparaceae) seed. The in vitro anti-inflammatory studies for the extract were done using protease inhibition activity, membrane stabilization, and albumin denaturation inhibition assays, and antioxidant activities were performed by determination of hydrogen peroxide (H2O2), nitric oxide (NO), and 2-2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity assays as well as total antioxidant capacity. The ethanol flavonoid-rich extract of B. coriacea seed was effective in inhibiting the denaturation of albumin in a concentration-dependent manner. The inhibitory ability of the extract on protease increased significantly (p < 0.05) with increased concentration. The flavonoid-rich extract of the seeds of B. coriacea like indomethacin significantly (p < 0.05) protected the human erythrocyte membrane against lyses induced by hypotonic solution when compared to the control. The plant extract at different concentrations inhibited significantly (p < 0.05) oxidative stress caused by HsO2, DPPH, NO radicals when compared to the control. The flavonoid-rich extract was found to possess radical scavenging and anti-inflammatory activities as determined by albumin denaturation, protease inhibition, membrane stabilization, hydrogen peroxides (H2O2) 2,2-Diphenyl-1-picrylhydrazyl (DPPH), Nitric oxide (NO) radical scavenging activities, and total antioxidant capacity data. Further research on isolating, purifying, and characterizing the particular class of flavonoids responsible for the aforementioned activities may be undertaken, and they may be incorporated into existing anti-inflammatory herbal compositions to improve their efficacy.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Natural and Applied Sciences |
| Depositing User: | Uchenna Eneogwe |
| Date Deposited: | 02 Jun 2025 09:28 |
| Last Modified: | 02 Jun 2025 09:28 |
| URI: | http://eprints.gouni.edu.ng/id/eprint/4718 |
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