ANTI DIABETIC EFFECT OF METHANOL EXTRACT OF MOMORDICA CHARANTIA LEAF IN ALLOXAN-INDUCED DIABETIC RATS.

Adalaka, Chukwudi M. (2018) ANTI DIABETIC EFFECT OF METHANOL EXTRACT OF MOMORDICA CHARANTIA LEAF IN ALLOXAN-INDUCED DIABETIC RATS. Other thesis, Godfrey Okoye University Ugwuomu Nike, Enugu.

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Abstract

Diabetes Mellitus (DM) is a leading cause of illness and death in developed countries and is epidemic in many developing and newly industrialized countries. Its macrovascular and microvascular complications are debilitating. The prevalence of diabetes in the world at all ages was estimated to be 2.8% in 2000,and it is expected to approximate 4.4% in the year 2030.The estimated global number of people of all ages and sex with diabetes in 2000 was 171 million. This is projected to increase to 366 million by 2030, with about 4 million deaths every year attributed to its complications (Abell et al., 1952; and American Diabetes Association 2007). The estimated number of people with diabetes in sub-Saharan Africa was 10.8 million in 2006, and this could rise to 18.7 million by 2025. Major risk factors are similar to those of other regions of the world such as urbanization, obesity, physical inactivity, or others that are not quite mutable such as increasing age and ethnicity. Most African countries still face a number of problems related to the management and treatment of the disease, such as critical shortage of diabetes medicine, the rising cost of drugs and treatment, competition for resources by HIV/AIDs, tuberculosis, and malaria. The general lack of equipment to diagnose the disease has hampered efforts to manage and control diabetes mellitus (American Diabetes Association, 2000 and American Diabetes Association, 2007). Anti-diabetic treatments or interventions are grouped into three major categories; diet and exercise which form part of first line treatment of diabetes, insulin and oral hypoglycaemic agents. However, the latter are often expensive and inaccessible to many low-income generating individuals in sub-Saharan Africa, given their high cost and the sometimes long distance that has to be travelled to the hospitals and health facilities that avail them. Also, these drugs are not without side effects and yet the treatment is life-long, due to the chronic nature of disease. Because of this, some patients use affordable and cost effective alternative therapy for management of diabetes in the form of traditional medicines, which are both locally available and cheap (American Diabetes Association, 2007 and Aebi, 1983).

Item Type:	Thesis (Other)
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Natural and Applied Sciences
Depositing User:	Mr Chukwudi M. Adalaka
Date Deposited:	30 Oct 2018 13:49
Last Modified:	30 Oct 2018 13:49
URI:	http://eprints.gouni.edu.ng/id/eprint/967

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