Relationship between G6PD, SOD and anemia in sickle cell patients

Ugwu, Onyinye (2018) Relationship between G6PD, SOD and anemia in sickle cell patients. Other thesis, Godfrey Okoye University Ugwuomu-Nike, Enugu.

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Abstract

The relationship between anemia, SOD (superoxide dismutase) and G6PD (glucose-6-phosphate) in SCD (sickle cell disease) patients were determined for the better understanding of their pathophysiology. Hemolytic anemia is one of the most common complications of sickle cell. It can be influenced by different factors, malaria infections, oxidative stress, dehydration, environmental stress and much more. SOD are enzymes that help with the regulation of oxidative stress and G6PD deficiency together with SCA are at high frequencies in malaria epidemic regions. Both SCA and G6PD deficiency patients suffer from anemia and can be said to coexist in some individuals. This study aims to find out the relationship between anemia, SOD and G6PD in SCD patients, if they coexist together or influence each other’s manifestations. A total of 70 patients were used including AA and AS genotypes as control. Anemia indices including hemoglobin (Hb) concentration, hematocrit were tested for. The presence of SOD and G6PD deficiency were tested for in all the patients. G6PD non deficient SS patients were 32.9% and 7.1% were deficient. The hemoglobin (Hb) concentration and hematocrit in SS patients were normal 6.76mg/dL which normally ranges from 5.0-10.0mg/dL. The SOD levels in SS were also at normal levels (2.45 10-1 U). There was no relationship between anemia, SOD and G6PD deficiency in sickle patients. These parameters can exist independently but cannot influence their prevalence as there was no interaction between G6PD deficiency and sickle cell to influence SOD level and anemia indices. However, anemia is associated with sickle cell disease.

Item Type: Thesis (Other)
Subjects: L Education > L Education (General)
Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Natural and Applied Sciences
Depositing User: Miss Onyinye Maryrose Ugwu
Date Deposited: 08 Oct 2018 10:14
Last Modified: 08 Oct 2018 10:14
URI: http://eprints.gouni.edu.ng/id/eprint/802

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