Tandem Catalysis of New Aza Angular Phenothiazine Ring Systems

Ayuk, E.L. and NJOKUNWOGBU, A.N and ILO, S.U. and Engwa, G.A. and Okoro, U.C and ONI, T.O. (2015) Tandem Catalysis of New Aza Angular Phenothiazine Ring Systems. American Journal of Organic Chemistry, 5 (2). pp. 78-81.

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Abstract

This communication deals with tandem synthesis of new aza angular phenothiazine ring systems of industrial importance via Suzuki-Miyaura reaction. 1,4-Bis-(2-hydroxy-3,5-di-tert-butyl)piperazine (ligand) was obtained by treating 40% paraformaldehyde solution, piperazine and 2,4-di-tert-butylphenol. This was combined with diphenylphospinobutane chloride Pd(dppb)Cl to form a complex catalyst system. 2-Aminopyridine-3-thiol one of the key intermediates was obtained through thiocyanation of 2-aminopyridine followed by alkaline hydrolysis of 2-amino-3-thiocyanatopyridine. 2-Aminopyridine-3-thiol was then treated with 2,3-dichloro-1,4-naphthoquinone to give a new aza angular phenothiazine ring which coupled with 3-chlorophenyl boronic acid in the presence of the complex catalyst system above to furnish another new phenothiazine polycyclic ring system 6-(3-chlorophenyl)-11-azabenzo[a] phenothiazin-5-one.

Item Type:	Article
Subjects:	L Education > L Education (General) Q Science > Q Science (General)
Divisions:	Faculty of Natural and Applied Sciences
Depositing User:	miss ifeoma agbo
Date Deposited:	18 Apr 2019 12:40
Last Modified:	18 Apr 2019 12:40
URI:	http://eprints.gouni.edu.ng/id/eprint/1175

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