51-Nucleotidase Activity In Albino Rats Treated With Talen® Tablets (Sedative)

Agbafor, Kingsley N. and Ossai, Emmanuel C. and Engwa, G.A. (2015) 51-Nucleotidase Activity In Albino Rats Treated With Talen® Tablets (Sedative). Journal of Pharmacy and Biological Sciences, 10 (5). pp. 54-59. ISSN 2278-3008

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Abstract

Sedative drugs have been used in the management and treatment of Insomnia, each produces some undesirable effects by various mechanisms. Talen®, containing the active ingredient; bromazepam has been used to treat insomnia effectively. This research work examined the hepatobiliary effect of the drug (Bromazepam) in albino rats. Twenty adult male albino rats, distributed into five (5) groups (A, B, C, D and E), with four (4) rats in each group were used in the research. Groups A, B, C and D were given oral treatment of 0.02, 0.04, 0.08 and 0.12mg/kg body weight of drug solution respectively, for seven consecutive days, while group E was kept as the control. Treatment of animals with the drug solution resulted to a decrease in physical activity, body weights, feed and water intake relative to the control. Measurement of the total protein concentration in the serum of the animals did not reveal any significant difference (P>0.05) between the test and the control groups. In contrast, the activity of 51-nucleotidase recorded in the treated groups were significantly higher (p<0.05) than the control. These effects varied with the doses. These findings suggested that Talen® may be toxic to the hepatobiliary system as revealed by increase in 51-Nucleotidase levels.

Item Type:	Article
Subjects:	L Education > L Education (General) Q Science > Q Science (General)
Divisions:	Faculty of Natural and Applied Sciences
Depositing User:	miss ifeoma agbo
Date Deposited:	18 Apr 2019 12:01
Last Modified:	18 Apr 2019 12:01
URI:	http://eprints.gouni.edu.ng/id/eprint/1173

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