The Effect of Aqueous Leaf Extract of Ageratum Conyzoides on Blood Glucose, Creatinine and Calcium Ion Levels in Albino Rats

Agbafor, Kingsley N. and Engwa, G.A. and Ude, C.M and OBIUDU, I.K. and Festus, B.O (2015) The Effect of Aqueous Leaf Extract of Ageratum Conyzoides on Blood Glucose, Creatinine and Calcium Ion Levels in Albino Rats. Journal of Pharmaceutical, Chemical and Biological Sciences, 3 (3). pp. 408-415. ISSN 2348-7658

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Abstract

Ageratum conyzoides has been known for its utilization in the treatment and management of several disorders, such as; diabetes, inflammations, spasm, headaches, cancers, among other, with little or no documentation. This present study examined the effect of leaf extract of Ageratum conyzoides on blood glucose, creatinine and calcium ion concentrations in albino rats. The research was carried out with twenty five (25) adult male albino rats. The animals were grouped into five (5), (1 to 5), with five (5) animals in each group. Doses of 150, 300, 450 and 600 mg/kg body weight of aqueous extract of fresh leaves of Ageratum conyzoides were orally administered to rats in groups 1, 2, 3 and 4 respectively, for seven (7) consecutive days, while group 5 served as the control. There was a significant decrease in physical activities, average body weight, and the rate of feed and water intake, in the test groups when compared with the control. Glucose and creatinine concentrations of the groups administrated with the aqueous extract of fresh leaves of Ageratum conyzoides decreased significantly (P < 0.05), when compared with the control. On the other hand, concentrations of calcium ion in groups administered with the extract and the control did not vary significantly (P > 0.05). This effect was found to vary among the doses. The findings of this research suggest that the leaf extract of Ageratum conyzoides may be useful in the management of blood sugar levels and kidney related disorders.

Item Type: Article
Subjects: L Education > L Education (General)
Q Science > Q Science (General)
Divisions: Faculty of Natural and Applied Sciences
Depositing User: miss ifeoma agbo
Date Deposited: 18 Apr 2019 11:57
Last Modified: 18 Apr 2019 11:57
URI: http://eprints.gouni.edu.ng/id/eprint/1172

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