Anti-hyperglycaemic Effect of Aqueous and Ethanolic Extract of Vernonia amygdalina on Alloxan Induced Albino Wistar Rat

Engwa, G.A. and Onyeka, N.T and TAGBO, Richard N. and OBIUDU, I.K. (2015) Anti-hyperglycaemic Effect of Aqueous and Ethanolic Extract of Vernonia amygdalina on Alloxan Induced Albino Wistar Rat. INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY, 4 (1). pp. 156-161. ISSN 2277 - 4688

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Abstract

Diabetes continue to threaten global health especially type II which is responsible for majority of the disease mortality. The continual search for solution has prompted the investigation of plant medicinal properties. Vernonia amygdalina among others has been shown to possess anti- diabetic properties in Nigeria but little or nothing has been reported on that cultivated in Enugu, hence the aim of this study. Twenty four wistar albino rats were divided into six groups. Group 1 to 5 animals were induced diabetes with alloxan and administered varying doses of aqueous and ethanol extract respectively for nine days expect for group 5 which served as negative control. Group 6; the positive control was non diabetic and did not receive plant extract. Serum was collected from whole blood, assayed for blood sugar concentration and the result was statistically analyzed. A significant difference was considered at p  0.05. After alloxan induction, the mean blood sugar level increased significantly (p  0.05) in groups 1 to 5 within a range of 269. 25 to 503.50 mg/dl compared to the positive control. And after, extract was administered, there was a significant reduction (p  0.05) in the mean sugar level in groups 1 to 4 (the extract administered groups) compared to the negative control. These results suggest that Vernonia amygdalina has an anti-hyperglycaemic effect and the ethanol extract was more effective than the aqueous extract in lowering blood sugar concentration in rats. Thus, this study confirms the antihyperglycaemic effect of Vernonia amygdalina cultivated in Enugu and recommends its consumption for the control and management of diabetes.

Item Type:	Article
Subjects:	L Education > L Education (General) Q Science > Q Science (General)
Divisions:	Faculty of Natural and Applied Sciences
Depositing User:	miss ifeoma agbo
Date Deposited:	18 Apr 2019 09:15
Last Modified:	18 Apr 2019 09:15
URI:	http://eprints.gouni.edu.ng/id/eprint/1160

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