Potential Antioxidant Activity of New Tetracyclic and Pentacyclic Nonlinear Phenothiazine Derivatives

Ayuk, E.L. and Engwa, G.A. and Igbojekwe, B.U. and Unaegbu, M. (2016) Potential Antioxidant Activity of New Tetracyclic and Pentacyclic Nonlinear Phenothiazine Derivatives. Biochemistry Research International. p. 8.

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Abstract

The global increase in oxidative stress related diseases such as cancer, cardiovascular, and inflammatory diseases caused by overwhelming level of free radicals in the body has encouraged the search for new antioxidant agents. Based on the ability of newlysynthesizedphenothiazinederivatives(6-chloro-11-azabenzo[a]phenothiazine-5-oneand6-[4-bromophenyl]-10-methyl-11azabenzo[a]phenothiazine-5-one)tooxidizeH2O2,aknownfreeradicaltosulfoxide,thisstudyassessedtheinvitroandinvivo antioxidant activity. The synthesized phenothiazine derivatives exhibited reducing power potential to convert Fe3+ to Fe2+ and high ability to scavenge H2O2 free radical in vitro. These activities were comparable to ascorbic acid, a standard antioxidant. The catalase activity significantly increased (

Item Type:	Article
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Faculty of Natural and Applied Sciences
Depositing User:	GOUNI ICT
Date Deposited:	05 May 2018 10:35
Last Modified:	05 May 2018 10:35
URI:	http://eprints.gouni.edu.ng/id/eprint/8

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