HYPOLIPIDEMIC AND ANTIOXIDANT CAPACITY OF METHANOL LEAF EXTRACT OF KIGELIA AFRICANA IN ALLOXAN-INDUCED DIABETIC RATS

Matthew, V. O. and Uhuo, E. N. (2018) HYPOLIPIDEMIC AND ANTIOXIDANT CAPACITY OF METHANOL LEAF EXTRACT OF KIGELIA AFRICANA IN ALLOXAN-INDUCED DIABETIC RATS. Other thesis, Godfrey Okoye University.

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Abstract

Diabetes mellitus is a metabolic disorder resulting from the presence of excess sugar in the blood as a result of defect of insulin secretion, insulin action or both. Insulin deficiency in turn leads to chronic hyperglycaemia with disturbances of carbohydrate fat and protein metabolism. Globally it has been estimated that the incidence of diabetes and project for year 2030, as given by international diabetes federation is 350million. This work is aimed at evaluating the antioxidant potential and hypolipidemic capacity of the plant. Methanol leaf extract of Kigelia africana used for the study. Alloxan diabetes was induced into 20 rats and the rats weighed 125g. They were grouped into four groups: group 1 Normal control group, group 2 diabetes not treated, group 3 diabetes treated with 0.6 g of modern drugs (glibenclamide), group 4 diabetes treated with 500 mg/kg body weight of the extract of K.africana orally for 14days. At the 14th day, rats were bled and blood samples obtained were used for parameter analysis. From the result, glucose level increased as the body weight of the rats in all test groups decreases when compared with normal control (group 1). Oral administration of K.africana causes an increase although not significant (P˂0.05) of MDA in the test group treated with leaf extract of K.africana (group 4) compared with other test groups. The result also showed a significant increase (P˂0.05) in Catalase (CAT) activity in diabetic rat treated with glibenclamide (group 3) and rats treated with leaf extract (group 4) when compared with normal groups (group 1&2). A significant increase (P˂0.05) was observed in the cholesterol level of diabetic rats treated with K.africana when compared with group1and 2. High density lipoprotein increased significantly (P˂0.05) in the test group (group 4) when compared with other test groups. Low density lipoprotein decreased significantly (P˂0.05) in the test group treated with K.africana leaf extract (group 4) compared with normal control (group 1). Therefore, from the results gotten, it can be said that Kigelia africana has an hypolipidemic and antioxidant Capacity in diabetic conditions.

Item Type: Thesis (Other)
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural and Applied Sciences
Depositing User: MISS VICTORIA OJOACHEONE MATTHEW
Date Deposited: 14 Aug 2018 11:02
Last Modified: 14 Aug 2018 11:02
URI: http://eprints.gouni.edu.ng/id/eprint/384

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