EFFECT OF MOMORDICA CHARANTIA LEAF FRACTIONS ON SERUM ELECTROLYTES AND RENAL FUNCTION INDICES IN ALLOXAN-INDUCED DIABETIC ALBINO RATS.

Nwankwo, Queendaline Chinelo EFFECT OF MOMORDICA CHARANTIA LEAF FRACTIONS ON SERUM ELECTROLYTES AND RENAL FUNCTION INDICES IN ALLOXAN-INDUCED DIABETIC ALBINO RATS. EFFECT OF MOMORDICA CHARANTIA LEAF FRACTIONS ON SERUM ELECTROLYTES AND RENAL FUNCTION INDICES IN ALLOXAN-INDUCED DIABETIC ALBINO RATS.. (Unpublished)

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EFFECT OF MOMORDICA CHARANTIA LEAF FRACTIONS ON SERUM ELECTROLYTES AND RENAL FUNCTION INDICES IN ALLOXAN-INDUCED DIABETIC ALBINO RATS..docx
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Abstract

Diabetes mellitus is the most common metabolic disorder in the community, plant like Momordica charantia can be used to correct this disorder. Momordica charantia, also known as bitter melon is a member of the family Cucurbittaceae. Seed, fruit and leave of this plant contain bioactive compounds with a wide range of biological activities that have been used in traditional medicine, in the treatment of several diseases including inflammation, infection and diabetes. The aim of this study is to investigate the effect of Momordica charantia fractions on some serum electrolytes and renal function indices in an alloxan induced albino rats. Fourty albino rats (180-274 g) were randomly divided into 8 groups with five in each group. The rats were injected intra-peritoneally with single dose of 100 mg/kg alloxan induced. Multiple doses 200 mg/kg of various fractions of plant extract were administered orally once daily for 14days. The rats were then sacrificed at 14th day and blood was collected for renal function test and electrolytes analysis using spectrophotometric method. The result showed that there was significant decrease (p>0.05) in srum level ( Na, K, Cl-) and in renal function indices ( Urea and Creatinine) as compared to the diabetic untreated groups. In conclusion, it has been shown that the leaf fractions of momordica charantia has a significant difference (P>0.05) in serum electrolytes and renal function indices.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Natural and Applied Sciences
Depositing User: Miss Queendaline Chinelo Nwankwo
Date Deposited: 31 Jul 2018 21:58
Last Modified: 31 Jul 2018 21:58
URI: http://eprints.gouni.edu.ng/id/eprint/374

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