THE RELATIONSHIP BETWEEN ANAEMIA, MALARIA AND ANTIOXIDANT STATUS IN PATIENT VISITING ENUGU STATE UNIVERSITY TEACHING HOSPITAL “ESUTH”

Anekwe, Chioma Queendaline THE RELATIONSHIP BETWEEN ANAEMIA, MALARIA AND ANTIOXIDANT STATUS IN PATIENT VISITING ENUGU STATE UNIVERSITY TEACHING HOSPITAL “ESUTH”. THE RELATIONSHIP BETWEEN ANAEMIA, MALARIA AND ANTIOXIDANT STATUS IN PATIENT VISITING ENUGU STATE UNIVERSITY TEACHING HOSPITAL “ESUTH”. (Unpublished)

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Abstract

Abstract Anemia is a condition that occurs when the amount of haemoglobin in a person’s drops below normal .and a decrease in haemoglobin is often associated with a decrease in the number of red blood cells and haematocrit which may be cause by malaria while Malaria is a major public health problem in Nigeria where it accounts for more cases and deaths than any other country in the world. Malaria is a risk for 97% of Nigeria’s population According to the World Health Organization (WHO), malaria is a significant public health problem in more than 100 countries and causes an estimated 200 million infections each year, with more than 500 thousand deaths annually. (WHO, 2011). Malaria is a disease cause by a plasmodium parasite transmitted by the bite of infected mosquitoes. One of the key contributory factors to the development and progression of its complication is that malaria may develop anaemia deficiency and malaria can generate free radicals that can possibly promote the development of anaemia and oxidative stress; a condition characterized by increase production of free radicals or impaired antioxidant defense system. An antioxidant which help in the removal of free radicals thereby preventing oxidative stress. Hence, this study was aimed to investigate the relationship between malaria infection, anemia deficiency and antioxidant status of patients visiting ESUTH Enugu. The study was conducted at ESUTH Enugu, were the formal concept patients was obtained from patients. A total 101 patients were recruited for the study, a questionnaire was use to collected a basic characteristic of the patients after which a blood sample was collected to measure the haemoglobin conc, haematocrit conc, vitamin C, catalase, SOD( superioxide dimutase) of a patients were screened through various tests conducted in laboratory. According to the results obtained, 58 (57.4%) patients were anaemic while (43(42.6%) were non anaemic. The haemoglobin (10.33±0.194) / (30.38±0.57), haematocrit (13.66±0.24)/ (40.07±0.73) levels were significant lower in anaemic patients than in the non anaemia patients (p- 0.001). While only the catalase showed a significant difference which elucidated that the catalase was higher in anaemic patents (1.45±0.03) compare to the non anaemia patients (1.35±0.03). Vitamin C and SOD conc level showed no significant between anaemic and non anaemic patients. There was no relationship between anaemia and malaria (p = 0.827). Also, there was no interaction between anaemia and malaria to influence the antioxidant indices as there was no significant difference among the anaemic and non-anaemic patients (p > 0.05). Findings from this study showed that there was no relationship between anaemia, malaria and antioxidant status of patient visiting ESUTH, Enugu.

Item Type:	Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Natural and Applied Sciences
Depositing User:	Miss Chioma Aniekwe
Date Deposited:	31 Jul 2018 21:56
Last Modified:	31 Jul 2018 21:56
URI:	http://eprints.gouni.edu.ng/id/eprint/367

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