The Effects of Ethanol Leaf-Extract of Albizia ferruginea on some Liver and Histopathological Parameters in Wistar Albino Rats

Ukpabi, S.E.N and Offor, C.E and Udeozor, P.A and OBIUDU, I.K. (2018) The Effects of Ethanol Leaf-Extract of Albizia ferruginea on some Liver and Histopathological Parameters in Wistar Albino Rats. International Digital Organization for Scientific Research, 3 (2). pp. 60-70. ISSN 2579-0811

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Abstract

The effects of ethanol leaf-extract of Albizia ferruginea on some liver and histopathological parameters were investigated using albino rats. Twenty four albino rats were randomly placed into four experimental groups (A, B, C and D) after seven days of acclimatization with six rats in each group. Animals in groups A, B, C and D were administered the ethanol leaf-extract of Albizia ferruginea at the doses of 0, 200, 400 and 600 mg/kg body weight respectively for fourteen days through oral intubation. The biochemical indices and histopathology were done using standard methods. The results showed that activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT) and the concentrations of total bilirubin and conjugated bilirubin significantly (p<0.05) increased dose-dependently. Total protein (TP) and albumin levels were significantly (p<0.05) decreased dose-dependently. There were severe damages of the liver of the test animals at groups C and D. The extract of Albizia ferruginea could be toxic if taken in excess and can cause liver damage.

Item Type:	Article
Subjects:	L Education > L Education (General) Q Science > Q Science (General)
Divisions:	Faculty of Natural and Applied Sciences
Depositing User:	miss ifeoma agbo
Date Deposited:	02 May 2019 13:03
Last Modified:	02 May 2019 13:03
URI:	http://eprints.gouni.edu.ng/id/eprint/1425

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