Relationship between Type 2 Diabetes and Glucose-6 Phosphate Dehydrogenase (G6PD) Deficiency and Their Effect on Oxidative Stress

Engwa, G.A. and Nwalo, Friday Nweke and Chibuzor, Gregory Eze and Ejiagha, Endaline Chiamaka and Abonyi, Micheal Chinweuba and Ugwu, Theophilus Ejiofor and OBIUDU, I.K. and Agbafor, Kingsley N. and Ojo, Opeolu Oyejide and Ubi, Benjamin Ewa (2018) Relationship between Type 2 Diabetes and Glucose-6 Phosphate Dehydrogenase (G6PD) Deficiency and Their Effect on Oxidative Stress. Journal of Diabetes and Metabolism, 9 (8). ISSN 2155-6156

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Official URL: http://10.4172/2155-6156.1000800


Objective: Though the relationship between glucose-6-phosphate dehydrogenase (G6PD) deficiency and type 2 diabetes (T2D) has been reported, their interaction to influence oxidative stress is not fully understood. This study was conducted to investigate the relationship between T2D and G6PD deficiency and assessed their effect on oxidative stress. Methodology: A total of 73 T2D and 75 non-diabetic (ND) out-patients at Enugu State University Teaching Hospital (ESUTH) in Enugu, Nigeria were recruited. They were screened for G6PD deficiency, oxidative stress markers; lipid peroxidation, protein peroxidation and glycated haemoglobin (HbA1c) and antioxidant enzymes; superoxide dismutase (SOD) and catalase activities were assayed. Results: Oxidative stress was influenced by T2D as malondialdehyde (MDA), protein carbonyl and HbA1c levels were significantly higher (p<0.05) in T2D patients compared to ND patients. Significantly (p<0.05) decreased SOD and catalase activity were also observed in T2D patients. G6PD deficiency and T2D showed a significant relationship (p<0.05) in male patients (χ2=5.070; p=0.024). Moreover, there was no significant (p>0.05) interaction between G6PD deficiency and T2D to influence oxidative stress in patients. Conclusion: The interaction between G6PD deficiency and T2D did not influence oxidative stress though there was a possible relationship between G6PD deficiency and T2D in male patients.

Item Type: Article
Subjects: L Education > L Education (General)
Q Science > Q Science (General)
Divisions: Faculty of Natural and Applied Sciences
Depositing User: miss ifeoma agbo
Date Deposited: 24 Apr 2019 10:05
Last Modified: 24 Apr 2019 10:05

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