Synthesis of Allosteric Modulators of CB1 Cannabinoid Receptors

UGWUONAH, LINDA (2018) Synthesis of Allosteric Modulators of CB1 Cannabinoid Receptors. Journal of Applied Chemistry, 11 (8). pp. 63-70. ISSN 2278-5736

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Abstract

Sample compounds that could act as allosteric modulators of CB1 cannabinoid receptors were synthesized. The compounds are analogues of pre-discovered bioactive molecules that bind to the CB1 allosteric site. Allosteric modulation could be a new effective approach to manipulating the endocannabinoid system by enhancing the signaling of already existing selective agonists, inverse agonists and enzyme inhibitors.Fischer indole synthesis, Vilsemeier-Haack reaction, InBr3-catalyzed sulphonation of indoles, reductive amination of indoles, bromination of indoles, were the synthesis reactions applied. Seven analogues were obtained. Percentage yield and melting point determination were performed for each compound. 1H and 13C NMR spectroscopy were also applied for characterization.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Natural and Applied Sciences
Depositing User: miss ifeoma agbo
Date Deposited: 17 Apr 2019 09:01
Last Modified: 17 Apr 2019 09:01
URI: http://eprints.gouni.edu.ng/id/eprint/1129

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