Investigation of the Phytochemicals and some Biological Parameters of Ficus sycomorus Leaf Extracts

Ayuk, E.L. and Nwochi, Samson Prince and Ogugor, Juliet C. (2019) Investigation of the Phytochemicals and some Biological Parameters of Ficus sycomorus Leaf Extracts. IOSR Journal Of Pharmacy And Biological Sciences, 14 (3). pp. 71-78. ISSN :2278-3008

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The presence of phytochemicals in plants is responsible for their medicinal values. This work is aimed at investigating the phytochemicals and antimicrobial activity of Ficus sycamorus leaf extracts. Ficus sycamorus leaf extracts of five different solvents namely; distilled water, ethanol, methanol, n-hexane, petroleum ether were screened for the presence of phytochemicals. The result of the phytochemical analysis revealed the presence of alkaloids, flavonoids steroid, glycosides and tannins. The above extracts were also subjected to antimicrobial analysis. The antimicrobial analyses of the Ficus sycamorus leaf extracts for the five solvents revealed different levels of biological activity against the microorganisms; Staphylococcus aerus, Escherichia coli, Pseudomonas aeruginosa, Penicillin chrysogenum, Aspergillus fumigatuss chrysogenum and Aspergillus fumigatuss respectively. Various zones of inhibition were observed when the extracts were administered against the microorganisms and their activity indices were determined by dividing the zones of inhibition of the extracts by the zones of inhibition of the standard drugs; amoxicillin for the bacteria and fluconazole for the fungi respectively. The results of the minimum inhibitory concentration (MIC) for the bacteria strands revealed that, the aqueous and n-hexane extracts have the same inhibitory concentrations of 500mg/ml respectively for Staph- aerus. Methanol and petroleum extracts showed MIC of 250mg/ml respectively for the above microorganism while the MIC for the ethanol extract against Staph- aerus was observed to be 125mg/ml. For the E. coil, the n-hexane and petroleum ether extracts showed MIC of 500mg/ml respectively, aqueous and ethanol extracts revealed MIC of 250mg/ml respectively while the MIC obtained for the methanol extract was 125mg/ml.In the case of P. aerusginosa, aqueous, n-hexane and petroleum ether extracts showed the same MIC of 500mg/ml respectively, methanol extract gave MIC of 250mg/ml while ethanol extract showed MIC of 125mg/ml. The MIC results for the fungi revealed thus; for P. chrysogenum, aqueous extract gave MIC of 500mg/ml and n-hexane showed MIC of 250mg/ml respectively. The values of MIC for methanol, ethanol and petroleum ether extracts respectively for P. chrysogenum were not observed at concentrations of 500mg/ml, 250mg/ml, 125mg/ml and 62.5mg/ml respectively. The presence of this microorganism was not notice. This implies that their MICs are lower than 62.5mg/ml. Also for A. fumigatus, its presence was not notice at concentrations of 500mg/ml, 250mg/ml, 125mg/ml and 62.5mg/ml in all the extracts. This also implies that their MICs for all the extracts are lower than 62.5mg/ml.

Item Type: Article
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Management and Social Sciences
Depositing User: mrs chioma hannah
Date Deposited: 04 Oct 2019 11:04
Last Modified: 04 Oct 2019 11:04

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