Changing Paradigms in Cell Biology: Their Implication and Possible Applications

Engwa, G.A. (2015) Changing Paradigms in Cell Biology: Their Implication and Possible Applications. Biochemistry & Physiology: Open Access, 4 (4). ISSN 2168-9652

[img] Text

Download (1MB)
Official URL:


The evolution of cell biology in the 20th century has evoked some remarkable changes in the existing paradigms. The discovery of alternative splicing, overlapping genes and protein splicing has shifted the one gene-one protein paradigm to several proteins. Proteins are no more the only catalytic macromolecule since the discovery of ribozymes. Genetic material was known to be stable in the genome and not mobile until the discovery of transposons. RNA editing has made possible the identification of certain missing genes and viruses are no longer considered the smallest infections agents after prions were discovered. Though not conclusive, recent findings suggest the possibility of transcription to occur in the nucleus. All these ground breaking discoveries are making substantial breakthrough in biological sciences particularly in understanding some cellular processes, their mechanisms on gene expression and regulation as well as the pathogenesis of certain illnesses. Also, these discoveries have revealed some potential drug targets and presently, some of the implicated biomolecules are being exploited for various pharmaceutical and biomedical applications.

Item Type: Article
Subjects: L Education > L Education (General)
Q Science > Q Science (General)
Divisions: Faculty of Natural and Applied Sciences
Depositing User: miss ifeoma agbo
Date Deposited: 18 Apr 2019 09:32
Last Modified: 18 Apr 2019 09:32

Actions (login required)

View Item View Item